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Department of Radiation Biophysics

С.М. Данильченко

Head of the Dept. PhD Danyl'chenko Serhii M. +3 (0542) 33-30-89, danil@ipflab.sumy.ua

 

Department staff (left to right): Stanislavov O.S., Illiashenko V.Yu Yanovs'ka A.A Pavlenko P.A., Danyl'chenko S.M., Kovalchuk V.M., Moskalenko V.B.

The main research areas are

    Radiation biophysics

  • development and testing of experimental basis for studying physical principles of radiation therapy viz channels of quazi-monochromatic X-ray (a) and single-particle mode of interaction (b);
  • development of methods for quantitative determination of ionizing radiation effect on biological objects to be used for detection and estimation of radiation damages (gel electrophoresis/«comet assay», chemiluminescence, histochemical methods);
  • development of methods for dosing irradiation of both single cells and subcellular structures and study of their influences; treatment and interpretation of experimental results with mathematical and computerized tools.
  • Isotope analysis - accelerator mass-spectrometry

  • design and development, testing and optimization of a complex automated system for analytical burning and graphitization of samples containing carbon to be used in accelerator mass-spectrometry with 14C isotope quantification ;
  • development of preparation methods for gas and solid samples for carbon isotope analysis with accelerator mass-spectrometry in biological tissues, cellular formations and biological liquids (for example, to study 14N+n→14C+p in living systems under neutron irradiation);
  • development of analytical techniques based on the accelerator mass-spectrometry to detect DNA adducts, products of tumor disintegration, antitumor drugs (including nanocomposite materials) using 14C isotope to be found in nano- and pico amounts in natural state.
  • Biomineralogy and biomaterials

  • synthesis of time-stable and radiation-resistant nanocomposite matrices (scaffolds) to immobilize cells and to form cell groups modelling cancer tumors for investigation of a complex effect of ionizing irradiation;
  • study of crystal chemical parameters of pathological calcium-phosphates in biological tissues (cancer and cardiovascular calcifications). Determination of carbonate substitution features in the structure of human heterotopic apatites. Study of micro-morphological and concentration distinctions of pathological calcificates of a different origin. Creation of a human pathological calcificate atlas/catalogue using microscopic and microanalytical data as well as structural and spectral methods. Modelling of generation dynamics of mineral-protein complexes and their degeneration into biopolymer-apatite nanocomposite particles in biological liquids and their artificial analogs oversaturated with calcium and phosphorus. Determination of compounds and inhibitors of pathological calcification and mechanisms of their action in the model systems.